miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Biochem Biophys Res Commun
; 411(3): 586-92, 2011 Aug 05.
Article
in En
| MEDLINE
| ID: mdl-21763284
ABSTRACT
Recent studies have revealed that microRNA-29c (miR-29c) is involved in a variety of biological processes including carcinogenesis. Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their corresponding controls. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key regulator in inflammation and immunity, was found to be inversely correlated with miR-29c levels and was identified as a target of miR-29c. Overexpression of miR-29c in HepG2.2.15 cells effectively suppressed TNFAIP3 expression and HBV DNA replication as well as inhibited cell proliferation and induced apoptosis. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting TNFAIP3. Thus miR-29c and TNFAIP3 represent key diagnostic markers and potential therapeutic targets for the prevention and treatment of HBV infection.
Full text:
1
Database:
MEDLINE
Main subject:
Nuclear Proteins
/
Gene Expression Regulation, Neoplastic
/
Hepatitis B virus
/
Carcinoma, Hepatocellular
/
MicroRNAs
/
Intracellular Signaling Peptides and Proteins
/
Liver Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Year:
2011
Type:
Article