Prediction of residues involved in inhibitor specificity in the dihydrofolate reductase family.

Goodey, N M; Herbert, K G; Hall, S M; Bagley, K C

Goodey, N M; Herbert, K G; Hall, S M; Bagley, K C.

Affiliation

Goodey NM; Montclair State University, Department of Chemistry and Biochemistry, Montclair, NJ 07043, USA. goodeyn@montclair.edu

Biochim Biophys Acta ; 1814(12): 1870-9, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21840427

Subject(s)

Enzyme Inhibitors/metabolism; Protein Interaction Mapping/methods; Tetrahydrofolate Dehydrogenase/chemistry; Tetrahydrofolate Dehydrogenase/metabolism; Animals; Computational Biology; Enzyme Inhibitors/chemistry; Escherichia coli/chemistry; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/metabolism; Folic Acid Antagonists/chemistry; Folic Acid Antagonists/metabolism; Forecasting; Humans; Models, Biological; Models, Molecular; Multigene Family; Mycobacterium/chemistry; Mycobacterium/enzymology; Mycobacterium/genetics; Mycobacterium/metabolism; Phylogeny; Protein Binding; Substrate Specificity; Tetrahydrofolate Dehydrogenase/genetics; Trypanosoma/chemistry; Trypanosoma/enzymology; Trypanosoma/genetics; Trypanosoma/metabolism

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Full text: 1 Database: MEDLINE Main subject: Tetrahydrofolate Dehydrogenase / Protein Interaction Mapping / Enzyme Inhibitors Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2011 Type: Article

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