Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay.

Mendoza, Renaldo; Petros, Andrew M; Liu, Yaya; Thimmapaya, Rama; Surowy, Carol S; Leise, Walter F; Pereda-Lopez, Ana; Panchal, Sanjay C; Sun, Chaohong

Mendoza, Renaldo; Petros, Andrew M; Liu, Yaya; Thimmapaya, Rama; Surowy, Carol S; Leise, Walter F; Pereda-Lopez, Ana; Panchal, Sanjay C; Sun, Chaohong.

Affiliation

Mendoza R; Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, United States.

Bioorg Med Chem Lett ; 21(18): 5248-50, 2011 Sep 15.

Article in En | MEDLINE | ID: mdl-21840712

Subject(s)

Enzyme Inhibitors/pharmacology; Nuclear Magnetic Resonance, Biomolecular/methods; Organic Chemicals/pharmacology; Transaminases/antagonists & inhibitors; Biocatalysis; Carbon Isotopes; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Ligands; Molecular Structure; Molecular Weight; Organic Chemicals/chemistry; Structure-Activity Relationship; Transaminases/chemistry; Transaminases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Organic Chemicals / Nuclear Magnetic Resonance, Biomolecular / Enzyme Inhibitors / Transaminases Type of study: Diagnostic_studies / Screening_studies Language: En Year: 2011 Type: Article

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