Receptor-isoform-selective insulin analogues give tissue-preferential effects.

Vienberg, Sara G; Bouman, Stephan D; Sørensen, Heidi; Stidsen, Carsten E; Kjeldsen, Thomas; Glendorf, Tine; Sørensen, Anders R; Olsen, Grith S; Andersen, Birgitte; Nishimura, Erica

Vienberg, Sara G; Bouman, Stephan D; Sørensen, Heidi; Stidsen, Carsten E; Kjeldsen, Thomas; Glendorf, Tine; Sørensen, Anders R; Olsen, Grith S; Andersen, Birgitte; Nishimura, Erica.

Affiliation

Vienberg SG; Department of Insulin Biology, Novo Nordisk A/S, Måløv, Denmark. savi@novonordisk.com

Biochem J ; 440(3): 301-8, 2011 Dec 15.

Article in En | MEDLINE | ID: mdl-21851336

Subject(s)

Hypoglycemic Agents/pharmacology; Insulin/analogs & derivatives; Receptor, Insulin/metabolism; Adipocytes/drug effects; Adipocytes/metabolism; Adipose Tissue/cytology; Adipose Tissue/metabolism; Animals; Binding, Competitive; Blood Glucose; Brain/metabolism; Cells, Cultured; Gene Expression; Glycogen/metabolism; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Insulin/pharmacology; Kidney/metabolism; Lipogenesis/drug effects; Liver/cytology; Liver/metabolism; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Myocardium/metabolism; Organ Specificity; Phosphorylation; Primary Cell Culture; Protein Isoforms/agonists; Protein Isoforms/genetics; Protein Isoforms/metabolism; Rats; Rats, Sprague-Dawley; Receptor, Insulin/agonists; Receptor, Insulin/genetics; Spleen/metabolism; Sus scrofa

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Full text: 1 Database: MEDLINE Main subject: Receptor, Insulin / Hypoglycemic Agents / Insulin Language: En Year: 2011 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptor, Insulin / Hypoglycemic Agents / Insulin Language: En Year: 2011 Type: Article