Mechanisms of NK cell activation: CD4(+) T cells enter the scene.
Cell Mol Life Sci
; 68(21): 3457-67, 2011 Nov.
Article
in En
| MEDLINE
| ID: mdl-21861183
ABSTRACT
Natural killer (NK) cells are innate lymphocytes involved in immunosurveillance through their cytotoxic activity and their capacity to secrete inflammatory cytokines. NK cell activation is necessary to initiate effector functions and results from a complex series of molecular and cellular events. We review here the signals that trigger NK cells and discuss recent findings showing that, besides antigen-presenting cells, T cells can play a central role in the initiation of NK cell activation in lymph nodes.
Full text:
1
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
CD4-Positive T-Lymphocytes
Limits:
Humans
Language:
En
Year:
2011
Type:
Article