Your browser doesn't support javascript.
loading
Wallerian degeneration: the innate-immune response to traumatic nerve injury.
Rotshenker, Shlomo.
Affiliation
  • Rotshenker S; Dept. of Medical Neurobiology, IMRIC, Hebrew University, Faculty of Medicine, Jerusalem, Israel. shlomor@ekmd.huji.ac.il
J Neuroinflammation ; 8: 109, 2011 Aug 30.
Article in En | MEDLINE | ID: mdl-21878125
ABSTRACT
Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed axons regenerate back to their target tissues. Innate-immunity is central to Wallerian degeneration since innate-immune cells, functions and molecules that are produced by immune and non-immune cells are involved. The innate-immune response helps to turn the peripheral nerve tissue into an environment that supports regeneration by removing inhibitory myelin and by upregulating neurotrophic properties. The characteristics of an efficient innate-immune response are rapid onset and conclusion, and the orchestrated interplay between Schwann cells, fibroblasts, macrophages, endothelial cells, and molecules they produce. Wallerian degeneration serves as a prelude for successful repair when these requirements are met. In contrast, functional recovery is poor when injury fails to produce the efficient innate-immune response of Wallerian degeneration.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Peripheral Nerves / Wallerian Degeneration / Trauma, Nervous System / Immunity, Innate Limits: Animals Language: En Year: 2011 Type: Article

Full text: 1 Database: MEDLINE Main subject: Peripheral Nerves / Wallerian Degeneration / Trauma, Nervous System / Immunity, Innate Limits: Animals Language: En Year: 2011 Type: Article