Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease.

Valles-Ortega, Jordi; Duran, Jordi; Garcia-Rocha, Mar; Bosch, Carles; Saez, Isabel; Pujadas, Lluís; Serafin, Anna; Cañas, Xavier; Soriano, Eduardo; Delgado-García, José M; Gruart, Agnès; Guinovart, Joan J

Valles-Ortega, Jordi; Duran, Jordi; Garcia-Rocha, Mar; Bosch, Carles; Saez, Isabel; Pujadas, Lluís; Serafin, Anna; Cañas, Xavier; Soriano, Eduardo; Delgado-García, José M; Gruart, Agnès; Guinovart, Joan J.

Affiliation

Valles-Ortega J; Institute for Research in Biomedicine (IRB Barcelona) Barcelona, Spain.

EMBO Mol Med ; 3(11): 667-81, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21882344

Subject(s)

Disease Models, Animal; Glycogen Synthase/metabolism; Lafora Disease/enzymology; Lafora Disease/physiopathology; Mice; Nerve Degeneration/enzymology; Animals; Astrocytes/enzymology; Female; Glycogen/metabolism; Glycogen Synthase/genetics; Hippocampus/enzymology; Humans; Inclusion Bodies/enzymology; Inclusion Bodies/genetics; Lafora Disease/genetics; Lafora Disease/pathology; Male; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration/genetics; Nerve Degeneration/pathology; Nerve Degeneration/physiopathology; Neurons/enzymology

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Full text: 1 Database: MEDLINE Main subject: Glycogen Synthase / Lafora Disease / Disease Models, Animal / Mice / Nerve Degeneration Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Year: 2011 Type: Article

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