Therapeutic plasma concentrations of antidepressants and antipsychotics: lessons from PET imaging.
Pharmacopsychiatry
; 44(6): 236-48, 2011 Sep.
Article
in En
| MEDLINE
| ID: mdl-21959785
ABSTRACT
Therapeutic Drug Monitoring (TDM) of psychotropic drugs is strongly depending on the validity of recommended therapeutic plasma concentration reference ranges. Rational pharmacotherapy is based on the assumption that plasma concentrations are directly related to target occupancy by the respective drug. Here we show that positron emission tomography (PET) of molecular drug targets in the brain (neuroreceptors and transporters) allows for establishment of these relationships, thereby providing guidance for TDM services. Associations between brain target occupancy, plasma concentrations, and clinical effects and adverse reactions will be discussed for the most commonly used antidepressant and antipsychotic drugs.
Full text:
1
Database:
MEDLINE
Main subject:
Antipsychotic Agents
/
Drug Monitoring
/
Positron-Emission Tomography
/
Molecular Targeted Therapy
/
Antidepressive Agents
Type of study:
Guideline
Limits:
Humans
Language:
En
Year:
2011
Type:
Article