CSF from amyotrophic lateral sclerosis patients produces glutamate independent death of rat motor brain cortical neurons: protection by resveratrol but not riluzole.

Yáñez, Matilde; Galán, Lucía; Matías-Guiu, Jorge; Vela, Alvaro; Guerrero, Antonio; García, Antonio G

Yáñez, Matilde; Galán, Lucía; Matías-Guiu, Jorge; Vela, Alvaro; Guerrero, Antonio; García, Antonio G.

Affiliation

Yáñez M; Instituto Teófilo Hernando and Departamento de Farmacología y Terapéutica, Universidad Autónoma de Madrid, Madrid, Spain. matilde.yannez@uam.es

Brain Res ; 1423: 77-86, 2011 Nov 14.

Article in En | MEDLINE | ID: mdl-21983205

Subject(s)

Amyotrophic Lateral Sclerosis/cerebrospinal fluid; Cerebral Cortex/cytology; Glutamic Acid/pharmacology; Motor Neurons/drug effects; Neuroprotective Agents/pharmacology; Stilbenes/pharmacology; Adult; Aged; Animals; Calcium/metabolism; Cell Death/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Embryo, Mammalian; Female; Humans; L-Lactate Dehydrogenase/metabolism; Male; Middle Aged; Pregnancy; Rats; Resveratrol; Riluzole/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Stilbenes / Cerebral Cortex / Neuroprotective Agents / Glutamic Acid / Amyotrophic Lateral Sclerosis / Motor Neurons Type of study: Clinical_trials Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged / Pregnancy Language: En Year: 2011 Type: Article

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