Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.

Stankowski, Leon F; Roberts, Daniel J; Chen, Hepei; Lawlor, Timothy; McKeon, Marie; Murli, Hemalatha; Thakur, Ajit; Xu, Yong

Stankowski, Leon F; Roberts, Daniel J; Chen, Hepei; Lawlor, Timothy; McKeon, Marie; Murli, Hemalatha; Thakur, Ajit; Xu, Yong.

Affiliation

Stankowski LF; Covance Laboratories, Vienna, Virginia, USA. leon.stankowski@bioreliance.com

Environ Mol Mutagen ; 52(9): 738-47, 2011 Dec.

Article in En | MEDLINE | ID: mdl-22020836

Subject(s)

4-Nitroquinoline-1-oxide/toxicity; Chromosome Aberrations/chemically induced; Membrane Proteins/genetics; Mutagenicity Tests; Mutagens/toxicity; Animals; Brain/drug effects; Brain/ultrastructure; CD59 Antigens/genetics; Calibration; Comet Assay/methods; Comet Assay/standards; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Endpoint Determination; Erythrocytes/drug effects; Erythrocytes/metabolism; Erythrocytes/ultrastructure; Laboratories/standards; Liver/drug effects; Liver/ultrastructure; Male; Micronucleus Tests/methods; Micronucleus Tests/standards; Mutagenicity Tests/methods; Mutagenicity Tests/standards; Organ Size/drug effects; Organ Specificity; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Reticulocytes/drug effects; Reticulocytes/metabolism; Reticulocytes/ultrastructure; Risk Assessment; Stomach/drug effects; Stomach/ultrastructure; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Chromosome Aberrations / Membrane Proteins / Mutagenicity Tests / Mutagens / 4-Nitroquinoline-1-oxide Type of study: Etiology_studies / Risk_factors_studies Language: En Year: 2011 Type: Article

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