Importin ß1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.

Kojima, Yuko; Nakayama, Masafumi; Nishina, Takashi; Nakano, Hiroyasu; Koyanagi, Makoto; Takeda, Kazuyoshi; Okumura, Ko; Yagita, Hideo

Kojima, Yuko; Nakayama, Masafumi; Nishina, Takashi; Nakano, Hiroyasu; Koyanagi, Makoto; Takeda, Kazuyoshi; Okumura, Ko; Yagita, Hideo.

Affiliation

Kojima Y; Laboratory of Biomedical Imaging Research, Biomedical Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. kojima-y@juntendo.ac.jp

J Biol Chem ; 286(50): 43383-93, 2011 Dec 16.

Article in En | MEDLINE | ID: mdl-22020938

Subject(s)

Cell Death/drug effects; Cell Nucleus/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism; TNF-Related Apoptosis-Inducing Ligand/pharmacology; beta Karyopherins/metabolism; Blotting, Western; Cell Line, Tumor; Flow Cytometry; HeLa Cells; Hep G2 Cells; Humans; Microscopy, Confocal; Protein Binding/drug effects; Protein Transport; RNA, Small Interfering; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; beta Karyopherins/genetics

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Full text: 1 Database: MEDLINE Main subject: Cell Nucleus / Cell Death / Beta Karyopherins / TNF-Related Apoptosis-Inducing Ligand / Receptors, TNF-Related Apoptosis-Inducing Ligand Type of study: Prognostic_studies Limits: Humans Language: En Year: 2011 Type: Article

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