The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.

Nahum, Amit; Dadi, Harjit; Bates, Andrea; Roifman, Chaim M

Nahum, Amit; Dadi, Harjit; Bates, Andrea; Roifman, Chaim M.

Affiliation

Nahum A; Division of Immunology & Allergy, Canadian Centre for Primary Immunodeficiency, Department of Pediatrics, The Hospital for Sick Children & The University of Toronto, Ontario, Canada.

Autoimmun Rev ; 11(5): 341-7, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22024499

Subject(s)

Autoimmunity/genetics; Candidiasis, Cutaneous/genetics; Cytomegalovirus Infections/genetics; Genetic Predisposition to Disease; Mutation; Skin Diseases, Viral/genetics; Toll-Like Receptor 3/genetics; Antibodies, Monoclonal/immunology; Autoimmunity/immunology; CD3 Complex/immunology; Candida albicans/immunology; Candidiasis, Cutaneous/immunology; Cytokines/immunology; Cytomegalovirus/immunology; Cytomegalovirus Infections/immunology; Dendritic Cells/immunology; Fibroblasts/immunology; Fibroblasts/metabolism; Genotype; Humans; Ligands; Lymphocyte Activation/immunology; Lymphocytes/immunology; Poly I-C/immunology; Skin Diseases, Viral/immunology; Toll-Like Receptor 3/immunology

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Full text: 1 Database: MEDLINE Main subject: Candidiasis, Cutaneous / Autoimmunity / Skin Diseases, Viral / Cytomegalovirus Infections / Genetic Predisposition to Disease / Toll-Like Receptor 3 / Mutation Limits: Humans Language: En Year: 2012 Type: Article

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