Inducible ASABF-type antimicrobial peptide from the sponge Suberites domuncula: microbicidal and hemolytic activity in vitro and toxic effect on molluscs in vivo.

Wiens, Matthias; Schröder, Heinz C; Korzhev, Michael; Wang, Xiao-Hong; Batel, Renato; Müller, Werner E G

Wiens, Matthias; Schröder, Heinz C; Korzhev, Michael; Wang, Xiao-Hong; Batel, Renato; Müller, Werner E G.

Affiliation

Wiens M; ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz D-55128, Germany.
Schröder HC; ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz D-55128, Germany.
Korzhev M; ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz D-55128, Germany.
Wang XH; ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz D-55128, Germany.
Batel R; Rudjer Boskovic Institute, Center for Marine Research, Giordano Paliaga 5, Rovinj HR-52210, Croatia.
Müller WEG; ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, Mainz D-55128, Germany.

Mar Drugs ; 9(10): 1969-1994, 2011.

Article in En | MEDLINE | ID: mdl-22073005

Subject(s)

Antimicrobial Cationic Peptides/pharmacology; Hemolytic Agents/pharmacology; Mollusca/drug effects; Suberites/chemistry; Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides/genetics; Apoptosis/drug effects; Gastropoda/drug effects; Gram-Positive Bacteria/drug effects; Microbial Sensitivity Tests; Molecular Sequence Data; Phylogeny; Real-Time Polymerase Chain Reaction; Recombinant Proteins/genetics; Sequence Analysis, Protein; Suberites/genetics

Key words

ASABF; Bittium sp; Suberites domuncula; antimicrobial peptides; apoptosis; sponges

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Full text: 1 Database: MEDLINE Main subject: Antimicrobial Cationic Peptides / Suberites / Hemolytic Agents / Mollusca Type of study: Prognostic_studies Limits: Animals Language: En Year: 2011 Type: Article

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