A new methodology for predicting human pharmacokinetics for inhaled drugs from oratracheal pharmacokinetic data in rats.

Jones, Rhys M; Harrison, Anthony

Jones, Rhys M; Harrison, Anthony.

Affiliation

Jones RM; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development Sandwich Laboratories, Sandwich, Kent, UK. rhys.jones@pfizer.com

Xenobiotica ; 42(1): 75-85, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22077102

Subject(s)

Bronchodilator Agents/pharmacokinetics; Adenosine/administration & dosage; Adenosine/analogs & derivatives; Adenosine/blood; Adenosine/pharmacokinetics; Administration, Inhalation; Albuterol/administration & dosage; Albuterol/analogs & derivatives; Albuterol/blood; Albuterol/pharmacokinetics; Androstadienes/administration & dosage; Androstadienes/blood; Androstadienes/pharmacokinetics; Animals; Biostatistics; Bronchodilator Agents/administration & dosage; Bronchodilator Agents/blood; Budesonide/administration & dosage; Budesonide/blood; Budesonide/pharmacokinetics; Ethanolamines/administration & dosage; Ethanolamines/blood; Ethanolamines/pharmacokinetics; Fluticasone; Formoterol Fumarate; Humans; Male; Pharmacokinetics; Rats; Salmeterol Xinafoate

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Full text: 1 Database: MEDLINE Main subject: Bronchodilator Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans / Male Language: En Year: 2012 Type: Article

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