Antifungal Agents/pharmacology; Cryptococcosis/microbiology; Cryptococcus neoformans/pathogenicity; Drug Resistance, Fungal; Flucytosine/pharmacology; Fungal Proteins/metabolism; Oxidative Stress; Transcription Factors/metabolism; Amino Acid Sequence; Animals; Cell Membrane/metabolism; Colony Count, Microbial; Conserved Sequence; Cryptococcosis/immunology; Cryptococcus neoformans/drug effects; Cryptococcus neoformans/physiology; DNA Damage; Ergosterol/biosynthesis; Female; Fungal Proteins/genetics; Gene Expression Profiling; Gene Expression Regulation, Fungal/drug effects; Gene Knockout Techniques; Genetic Pleiotropy; Lung/immunology; Lung/microbiology; Lung/pathology; Mice; Microbial Viability/drug effects; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Kinases/metabolism; Transcription Factors/genetics; Virulence; Virulence Factors/biosynthesis