Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.

Habib, Tania; Funk, Andrew; Rieck, Mary; Brahmandam, Archana; Dai, Xuezhi; Panigrahi, Anil K; Luning Prak, Eline T; Meyer-Bahlburg, Almut; Sanda, Srinath; Greenbaum, Carla; Rawlings, David J; Buckner, Jane H

Habib, Tania; Funk, Andrew; Rieck, Mary; Brahmandam, Archana; Dai, Xuezhi; Panigrahi, Anil K; Luning Prak, Eline T; Meyer-Bahlburg, Almut; Sanda, Srinath; Greenbaum, Carla; Rawlings, David J; Buckner, Jane H.

Affiliation

Habib T; Translational Research Program, Benaroya Research Institute, Seattle, WA 98101, USA.

J Immunol ; 188(1): 487-96, 2012 Jan 01.

Article in En | MEDLINE | ID: mdl-22105996

Subject(s)

Alleles; B-Lymphocyte Subsets/immunology; Diabetes Mellitus, Type 1; Immune Tolerance/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Signal Transduction; Autoantibodies/genetics; Autoantibodies/immunology; Clonal Anergy/genetics; Clonal Anergy/immunology; Diabetes Mellitus, Type 1/genetics; Diabetes Mellitus, Type 1/immunology; Female; Genotype; Homeostasis/genetics; Homeostasis/immunology; Humans; Male; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 22/immunology; Receptors, Antigen, B-Cell/genetics; Receptors, Antigen, B-Cell/immunology; Signal Transduction/genetics; Signal Transduction/immunology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Signal Transduction / B-Lymphocyte Subsets / Diabetes Mellitus, Type 1 / Alleles / Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Immune Tolerance Type of study: Clinical_trials / Risk_factors_studies Limits: Female / Humans / Male Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google