Prothymosin-&#945; interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

Dong, Gaofeng; Callegari, Eduardo A; Gloeckner, Christian J; Ueffing, Marius; Wang, Hongmin

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

Dong, Gaofeng; Callegari, Eduardo A; Gloeckner, Christian J; Ueffing, Marius; Wang, Hongmin.

Affiliation

Dong G; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA.

J Biol Chem ; 287(2): 1279-89, 2012 Jan 06.

Article in En | MEDLINE | ID: mdl-22110140

Subject(s)

Nerve Tissue Proteins/metabolism; Nuclear Proteins/metabolism; Protein Precursors/metabolism; Thymosin/analogs & derivatives; Amino Acid Sequence; Caspase 3/genetics; Caspase 3/metabolism; Cell Death/drug effects; Enzyme Activation/drug effects; HEK293 Cells; Humans; Huntingtin Protein; Huntington Disease/drug therapy; Huntington Disease/genetics; Huntington Disease/metabolism; Mutation; Nerve Tissue Proteins/genetics; Nuclear Proteins/genetics; Protein Binding; Protein Precursors/genetics; Protein Precursors/pharmacology; Protein Structure, Tertiary; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology; Sequence Deletion; Thymosin/genetics; Thymosin/metabolism; Thymosin/pharmacology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Protein Precursors / Thymosin / Nuclear Proteins / Nerve Tissue Proteins Limits: Humans Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Protein Precursors / Thymosin / Nuclear Proteins / Nerve Tissue Proteins Limits: Humans Language: En Year: 2012 Type: Article