Inhibition of pathological retinal angiogenesis by the integrin &#945;vß3 antagonist tetraiodothyroacetic acid (tetrac).

Yoshida, Takeshi; Gong, Junsong; Xu, Zhenhua; Wei, Yanhong; Duh, Elia J

Inhibition of pathological retinal angiogenesis by the integrin αvß3 antagonist tetraiodothyroacetic acid (tetrac).

Yoshida, Takeshi; Gong, Junsong; Xu, Zhenhua; Wei, Yanhong; Duh, Elia J.

Affiliation

Yoshida T; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N. Broadway, Baltimore, MD 21287, USA.

Exp Eye Res ; 94(1): 41-8, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22123068

Subject(s)

Angiogenesis Inhibitors/pharmacology; Integrin alphaVbeta3/antagonists & inhibitors; Retinal Neovascularization/prevention & control; Thyroxine/analogs & derivatives; Animals; Blotting, Western; Cell Movement/drug effects; Cell Proliferation/drug effects; Cell Survival; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Erythropoietin/antagonists & inhibitors; Erythropoietin/pharmacology; Humans; Intravitreal Injections; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Oxygen/toxicity; Phosphorylation; Retinal Neovascularization/metabolism; Retinal Neovascularization/pathology; Thyroxine/pharmacology; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor A/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Thyroxine / Retinal Neovascularization / Angiogenesis Inhibitors / Integrin alphaVbeta3 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2012 Type: Article

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