PRDM1 is a tumor suppressor gene in natural killer cell malignancies.

Küçük, Can; Iqbal, Javeed; Hu, Xiaozhou; Gaulard, Phillip; De Leval, Laurence; Srivastava, Gopesh; Au, Wing Yan; McKeithan, Timothy W; Chan, Wing C

Küçük, Can; Iqbal, Javeed; Hu, Xiaozhou; Gaulard, Phillip; De Leval, Laurence; Srivastava, Gopesh; Au, Wing Yan; McKeithan, Timothy W; Chan, Wing C.

Affiliation

Küçük C; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Proc Natl Acad Sci U S A ; 108(50): 20119-24, 2011 Dec 13.

Article in En | MEDLINE | ID: mdl-22143801

Subject(s)

Killer Cells, Natural/pathology; Lymphoma, Non-Hodgkin/genetics; Lymphoma, Non-Hodgkin/pathology; Repressor Proteins/genetics; Tumor Suppressor Proteins/genetics; Apoptosis/drug effects; Biopsy; Cell Division/drug effects; Cell Division/genetics; Culture Media/pharmacology; DNA Copy Number Variations/drug effects; DNA Copy Number Variations/genetics; DNA Methylation/drug effects; DNA Methylation/genetics; DNA Mutational Analysis; G2 Phase/drug effects; G2 Phase/genetics; Gene Expression Regulation, Neoplastic/drug effects; Gene Knockdown Techniques; Gene Silencing/drug effects; Humans; Interleukin-2/metabolism; Interleukin-2/pharmacology; Killer Cells, Natural/drug effects; Killer Cells, Natural/metabolism; Positive Regulatory Domain I-Binding Factor 1; Promoter Regions, Genetic/genetics; RNA, Small Interfering/metabolism; Repressor Proteins/metabolism; Time Factors; Transduction, Genetic; Tumor Suppressor Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Repressor Proteins / Lymphoma, Non-Hodgkin / Killer Cells, Natural / Tumor Suppressor Proteins Type of study: Prognostic_studies Limits: Humans Language: En Year: 2011 Type: Article

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