Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption.

Chang, Chih-Peng; Yang, Ming-Chen; Lei, Huan-Yao

Chang, Chih-Peng; Yang, Ming-Chen; Lei, Huan-Yao.

Affiliation

Chang CP; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

PLoS One ; 6(12): e28323, 2011.

Article in En | MEDLINE | ID: mdl-22163006

Subject(s)

Autophagy; Concanavalin A/metabolism; GTP-Binding Proteins/metabolism; Hepatocytes/cytology; Animals; Carcinoma, Hepatocellular/metabolism; Cathepsin B/metabolism; Cathepsin L/metabolism; Cell Line, Tumor; Cell Membrane/metabolism; Endocytosis; Hep G2 Cells; Humans; Interferon-gamma/metabolism; Liver Neoplasms/metabolism; Lysosomes/metabolism; Mice; Mice, Inbred BALB C; Necrosis; Permeability

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Concanavalin A / GTP-Binding Proteins / Hepatocytes Limits: Animals / Humans Language: En Year: 2011 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Autophagy / Concanavalin A / GTP-Binding Proteins / Hepatocytes Limits: Animals / Humans Language: En Year: 2011 Type: Article