G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gß and G&#945;i protein subunits.

Giguère, Patrick M; Laroche, Geneviève; Oestreich, Emily A; Siderovski, David P

G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gß and Gαi protein subunits.

Giguère, Patrick M; Laroche, Geneviève; Oestreich, Emily A; Siderovski, David P.

Affiliation

Giguère PM; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7365, USA.

J Biol Chem ; 287(7): 4863-74, 2012 Feb 10.

Article in En | MEDLINE | ID: mdl-22167191

Subject(s)

GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; GTP-Binding Protein beta Subunits/metabolism; Guanine Nucleotide Dissociation Inhibitors/metabolism; Multiprotein Complexes/metabolism; Animals; COS Cells; Chaperonin Containing TCP-1/genetics; Chaperonin Containing TCP-1/metabolism; Chlorocebus aethiops; Enzyme Activation/physiology; GTP-Binding Protein alpha Subunits, Gi-Go/genetics; GTP-Binding Protein beta Subunits/genetics; Guanine Nucleotide Dissociation Inhibitors/genetics; HEK293 Cells; Humans; Multiprotein Complexes/genetics; Phospholipase C beta/genetics; Phospholipase C beta/metabolism

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Full text: 1 Database: MEDLINE Main subject: GTP-Binding Protein alpha Subunits, Gi-Go / Guanine Nucleotide Dissociation Inhibitors / GTP-Binding Protein beta Subunits / Multiprotein Complexes Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Year: 2012 Type: Article

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