A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression.

Tamura, Kunihiro; Kanno, Takeshi; Fujita, Yumiko; Gotoh, Akinobu; Nakano, Takashi; Nishizaki, Tomoyuki

Tamura, Kunihiro; Kanno, Takeshi; Fujita, Yumiko; Gotoh, Akinobu; Nakano, Takashi; Nishizaki, Tomoyuki.

Affiliation

Tamura K; Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.

J Cell Biochem ; 113(5): 1766-75, 2012 May.

Article in En | MEDLINE | ID: mdl-22213163

Subject(s)

Apoptosis/physiology; BH3 Interacting Domain Death Agonist Protein/metabolism; Receptor, Adenosine A2A/metabolism; bcl-X Protein/metabolism; Adenosine/pharmacology; Adenosine A2 Receptor Agonists/pharmacology; Apoptosis/drug effects; Apoptosis/genetics; BH3 Interacting Domain Death Agonist Protein/genetics; Base Sequence; Caspases/metabolism; Cytochromes c/metabolism; Down-Regulation; Gene Knockdown Techniques; Hep G2 Cells; Hepatocytes/cytology; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Membrane Potential, Mitochondrial/drug effects; Mitochondria, Liver/drug effects; Mitochondria, Liver/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; Receptor, Adenosine A2A/deficiency; Receptor, Adenosine A2A/genetics; Signal Transduction; Up-Regulation; bcl-X Protein/genetics

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Full text: 1 Database: MEDLINE Main subject: Apoptosis / Receptor, Adenosine A2A / Bcl-X Protein / BH3 Interacting Domain Death Agonist Protein Limits: Humans Language: En Year: 2012 Type: Article

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