Local but not systemic capillary lactate is a reperfusion biomarker in experimental acute limb ischaemia.
Eur J Vasc Endovasc Surg
; 43(3): 339-40, 2012 Mar.
Article
in En
| MEDLINE
| ID: mdl-22237513
ABSTRACT
INTRODUCTION:
Systemic capillary lactate, an end product of cellular anaerobic metabolism, has not established credibility in monitoring limb reperfusion. We assessed, in mice, whether local capillary lactate, arising from the reperfused limb, might be a relevant biomarker of reperfusion. REPORT Systemic and local capillary lactate were sampled in the non-ischaemic and in the ischaemic limb. Only local lactate concentrations significantly increased after 2 h of ischaemia and decreased after reperfusion.DISCUSSION:
Local, but not systemic, capillary lactate appeared as a potential reperfusion biomarker in this experimental acute limb ischaemia model.
Full text:
1
Database:
MEDLINE
Main subject:
Capillaries
/
Muscle, Skeletal
/
Lactic Acid
/
Hindlimb
/
Ischemia
Limits:
Animals
Language:
En
Year:
2012
Type:
Article