Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.

Ray, Paramita; Lewin, Sarah A; Mihalko, Laura Anne; Schmidt, Bradley T; Luker, Kathryn E; Luker, Gary D

Ray, Paramita; Lewin, Sarah A; Mihalko, Laura Anne; Schmidt, Bradley T; Luker, Kathryn E; Luker, Gary D.

Affiliation

Ray P; Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.

Neoplasia ; 13(12): 1152-61, 2011 Dec.

Article in En | MEDLINE | ID: mdl-22241961

Subject(s)

Chemokine CXCL12/antagonists & inhibitors; Molecular Imaging; Ovarian Neoplasms/metabolism; Receptors, CXCR4/antagonists & inhibitors; Recombinant Fusion Proteins/antagonists & inhibitors; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/pharmacology; Benzylamines; Cell Line, Tumor; Chemokine CXCL12/genetics; Chemokine CXCL12/metabolism; Cyclams; Female; Genes, Reporter; Heterocyclic Compounds/administration & dosage; Heterocyclic Compounds/pharmacology; Humans; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Molecular Targeted Therapy; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/genetics; Protein Binding; Receptors, CXCR4/genetics; Receptors, CXCR4/metabolism; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction/drug effects

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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms / Recombinant Fusion Proteins / Receptors, CXCR4 / Chemokine CXCL12 / Molecular Imaging Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2011 Type: Article

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