IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci.

Lee, Eunyoung; Chanamara, Sarah; Pleasure, David; Soulika, Athena M

Lee, Eunyoung; Chanamara, Sarah; Pleasure, David; Soulika, Athena M.

Affiliation

Lee E; Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, California 95817, USA.

J Neuroinflammation ; 9: 7, 2012 Jan 16.

Article in En | MEDLINE | ID: mdl-22248039

Subject(s)

Central Nervous System/immunology; Central Nervous System/metabolism; Encephalomyelitis, Autoimmune, Experimental/pathology; Signal Transduction/immunology; Animals; Antigens, CD/metabolism; Blood-Brain Barrier/physiopathology; Central Nervous System/drug effects; Central Nervous System/pathology; Cytokines/metabolism; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental/chemically induced; Encephalomyelitis, Autoimmune, Experimental/complications; Encephalomyelitis, Autoimmune, Experimental/immunology; Flow Cytometry; Glycoproteins/adverse effects; Interferon-gamma/deficiency; Leukocyte Common Antigens/genetics; Leukocytes/drug effects; Leukocytes/immunology; Lymph Nodes/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Oligodendrocyte Glycoprotein; Nervous System Diseases/etiology; Neutrophil Infiltration/drug effects; Neutrophil Infiltration/immunology; Peptide Fragments/adverse effects; Signal Transduction/drug effects; Spleen/pathology

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Central Nervous System / Encephalomyelitis, Autoimmune, Experimental Type of study: Etiology_studies Limits: Animals Language: En Year: 2012 Type: Article

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