Phylodynamic and phylogeographic patterns of the HIV type 1 subtype F1 parenteral epidemic in Romania.
AIDS Res Hum Retroviruses
; 28(9): 1161-6, 2012 Sep.
Article
in En
| MEDLINE
| ID: mdl-22251065
ABSTRACT
In the late 1980s an HIV-1 epidemic emerged in Romania that was dominated by subtype F1. The main route of infection is believed to be parenteral transmission in children. We sequenced partial pol coding regions of 70 subtype F1 samples from children and adolescents from the PENTA-EPPICC network of which 67 were from Romania. Phylogenetic reconstruction using the sequences and other publically available global subtype F sequences showed that 79% of Romanian F1 sequences formed a statistically robust monophyletic cluster. The monophyletic cluster was epidemiologically linked to parenteral transmission in children. Coalescent-based analysis dated the origins of the parenteral epidemic to 1983 [1981-1987; 95% HPD]. The analysis also shows that the epidemic's effective population size has remained fairly constant since the early 1990s suggesting limited onward spread of the virus within the population. Furthermore, phylogeographic analysis suggests that the root location of the parenteral epidemic was Bucharest.
Full text:
1
Database:
MEDLINE
Main subject:
Phylogeny
/
HIV-1
/
HIV Seropositivity
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Infectious Disease Transmission, Vertical
/
Pol Gene Products, Human Immunodeficiency Virus
Type of study:
Health_economic_evaluation
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
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Female
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Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Year:
2012
Type:
Article