Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.

De Pascalis, Roberto; Chou, Alicia Y; Bosio, Catharine M; Huang, Chiung-Yu; Follmann, Dean A; Elkins, Karen L

De Pascalis, Roberto; Chou, Alicia Y; Bosio, Catharine M; Huang, Chiung-Yu; Follmann, Dean A; Elkins, Karen L.

Affiliation

De Pascalis R; Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, United States of America.

PLoS Pathog ; 8(1): e1002494, 2012 Jan.

Article in En | MEDLINE | ID: mdl-22275868

Subject(s)

Bacterial Vaccines; Biomarkers/metabolism; Francisella tularensis/immunology; Tularemia/prevention & control; Animals; Bacterial Vaccines/standards; Coculture Techniques; Cytokines/genetics; Cytokines/immunology; Disease Models, Animal; Francisella tularensis/genetics; Francisella tularensis/growth & development; Gene Expression Regulation, Bacterial/genetics; Kaplan-Meier Estimate; Lymphocytes/cytology; Lymphocytes/immunology; Macrophages/cytology; Macrophages/microbiology; Male; Mice; Mice, Inbred C57BL; Spleen/cytology; Spleen/immunology; Tularemia/immunology; Tularemia/microbiology; Up-Regulation/genetics; Vaccines, Attenuated/standards

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Tularemia / Bacterial Vaccines / Biomarkers / Francisella tularensis Type of study: Prognostic_studies Limits: Animals Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google