Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

Jian, Cui; Xiao, Juan; Gong, Lingjie; Skipwith, Christopher G; Jin, Sheng-Yu; Kwaan, Hau C; Zheng, X Long

Jian, Cui; Xiao, Juan; Gong, Lingjie; Skipwith, Christopher G; Jin, Sheng-Yu; Kwaan, Hau C; Zheng, X Long.

Affiliation

Jian C; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, PA 19104, USA.

Blood ; 119(16): 3836-43, 2012 Apr 19.

Article in En | MEDLINE | ID: mdl-22289888

Subject(s)

ADAM Proteins/genetics; ADAM Proteins/immunology; Autoantibodies/immunology; Purpura, Thrombotic Thrombocytopenic/genetics; Purpura, Thrombotic Thrombocytopenic/immunology; ADAM Proteins/chemistry; ADAMTS13 Protein; Adult; Aged; Animals; Antibody Specificity; Binding Sites, Antibody/immunology; COS Cells; Chlorocebus aethiops; Female; Genetic Variation; Humans; Immunoglobulin G/immunology; Immunotherapy/methods; Male; Middle Aged; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Purpura, Thrombotic Thrombocytopenic/therapy; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/immunology; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Purpura, Thrombotic Thrombocytopenic / Autoantibodies / ADAM Proteins Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Year: 2012 Type: Article

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