Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang, Siu Man; Brown, Louise; Lin, Kuang; Liu, Li; Piper, Kim; O'Toole, Edel A; Grose, Richard; Hart, Ian R; Garrod, David R; Fortune, Farida; Wan, Hong

Tsang, Siu Man; Brown, Louise; Lin, Kuang; Liu, Li; Piper, Kim; O'Toole, Edel A; Grose, Richard; Hart, Ian R; Garrod, David R; Fortune, Farida; Wan, Hong.

Affiliation

Tsang SM; Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, UK.

J Pathol ; 227(1): 81-93, 2012 May.

Article in En | MEDLINE | ID: mdl-22294297

Subject(s)

Cadherins/metabolism; Desmoglein 3/genetics; Gene Expression Regulation; Pemphigus/genetics; Protein-Tyrosine Kinases/genetics; CSK Tyrosine-Protein Kinase; Cell Adhesion/genetics; Cell Line; Desmoglein 3/metabolism; Enzyme Activation; Gene Silencing; Humans; Keratinocytes/metabolism; Keratinocytes/pathology; Mouth Mucosa/metabolism; Mouth Mucosa/pathology; Pemphigus/metabolism; Pemphigus/pathology; Protein-Tyrosine Kinases/metabolism; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Signal Transduction; Transfection; src-Family Kinases

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Full text: 1 Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cadherins / Gene Expression Regulation / Pemphigus / Desmoglein 3 Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Year: 2012 Type: Article

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