Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells.

Hirsch, Andrea; Hahn, Dagmar; Kempná, Petra; Hofer, Gaby; Mullis, Primus E; Nuoffer, Jean-Marc; Flück, Christa E

Hirsch, Andrea; Hahn, Dagmar; Kempná, Petra; Hofer, Gaby; Mullis, Primus E; Nuoffer, Jean-Marc; Flück, Christa E.

Affiliation

Hirsch A; Division of Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland.

PLoS One ; 7(1): e30956, 2012.

Article in En | MEDLINE | ID: mdl-22295121

Subject(s)

AMP-Activated Protein Kinases/metabolism; Adrenal Glands/cytology; Adrenal Glands/metabolism; Androgens/biosynthesis; Steroids/biosynthesis; AMP-Activated Protein Kinases/antagonists & inhibitors; AMP-Activated Protein Kinases/deficiency; AMP-Activated Protein Kinases/genetics; Adrenal Glands/drug effects; Adrenal Glands/enzymology; Animals; Cell Line; Cell Proliferation/drug effects; Culture Media, Serum-Free; Female; Gene Expression Regulation, Enzymologic/drug effects; Gene Knockdown Techniques; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; Mitochondria/drug effects; Mitochondria/metabolism; Phosphorylation/drug effects; Protein Subunits/antagonists & inhibitors; Protein Subunits/deficiency; Protein Subunits/genetics; Protein Subunits/metabolism; Pyrazoles/pharmacology; Pyrimidines/pharmacology; RNA, Small Interfering/genetics; Signal Transduction/drug effects; Steroid 17-alpha-Hydroxylase/metabolism; Swine

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Full text: 1 Database: MEDLINE Main subject: Steroids / Adrenal Glands / AMP-Activated Protein Kinases / Androgens Limits: Animals / Female / Humans Language: En Year: 2012 Type: Article

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