Fluvoxamine increased glutamate release by activating both 5-HT(3) and sigma-1 receptors in prelimbic cortex of chronic restraint stress C57BL/6 mice.

Fu, Yingmei; Yu, Shunying; Guo, Xiaoyun; Li, Xia; Li, Ting; Li, Huafang; Dong, Yi

Fu, Yingmei; Yu, Shunying; Guo, Xiaoyun; Li, Xia; Li, Ting; Li, Huafang; Dong, Yi.

Affiliation

Fu Y; Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Biochim Biophys Acta ; 1823(4): 826-37, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22306004

Subject(s)

Cerebral Cortex/metabolism; Fluvoxamine/pharmacology; Glutamic Acid/metabolism; Limbic System/metabolism; Receptors, Serotonin, 5-HT3/metabolism; Receptors, sigma/metabolism; Stress, Physiological/drug effects; Animals; Benzophenanthridines/pharmacology; Calcium/metabolism; Calcium Channel Blockers/pharmacology; Cerebral Cortex/drug effects; Chronic Disease; Egtazic Acid/pharmacology; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/metabolism; Fluvoxamine/administration & dosage; Limbic System/drug effects; Male; Mice; Mice, Inbred C57BL; Models, Biological; Protein Kinase C/metabolism; Receptors, sigma/agonists; Restraint, Physical; Serotonin 5-HT3 Receptor Antagonists/pharmacology; Synapses/drug effects; Synapses/metabolism; Synaptosomes/drug effects; Synaptosomes/metabolism; Sigma-1 Receptor

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Full text: 1 Database: MEDLINE Main subject: Stress, Physiological / Cerebral Cortex / Fluvoxamine / Receptors, sigma / Glutamic Acid / Receptors, Serotonin, 5-HT3 / Limbic System Type of study: Prognostic_studies Limits: Animals Language: En Year: 2012 Type: Article

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