Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.

Rossi, Davide; Fangazio, Marco; Rasi, Silvia; Vaisitti, Tiziana; Monti, Sara; Cresta, Stefania; Chiaretti, Sabina; Del Giudice, Ilaria; Fabbri, Giulia; Bruscaggin, Alessio; Spina, Valeria; Deambrogi, Clara; Marinelli, Marilisa; Famà, Rosella; Greco, Mariangela; Daniele, Giulia; Forconi, Francesco; Gattei, Valter; Bertoni, Francesco; Deaglio, Silvia; Pasqualucci, Laura; Guarini, Anna; Dalla-Favera, Riccardo; Foà, Robin; Gaidano, Gianluca

Rossi, Davide; Fangazio, Marco; Rasi, Silvia; Vaisitti, Tiziana; Monti, Sara; Cresta, Stefania; Chiaretti, Sabina; Del Giudice, Ilaria; Fabbri, Giulia; Bruscaggin, Alessio; Spina, Valeria; Deambrogi, Clara; Marinelli, Marilisa; Famà, Rosella; Greco, Mariangela; Daniele, Giulia; Forconi, Francesco; Gattei, Valter; Bertoni, Francesco; Deaglio, Silvia; Pasqualucci, Laura; Guarini, Anna; Dalla-Favera, Riccardo; Foà, Robin; Gaidano, Gianluca.

Affiliation

Rossi D; Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy. rossidav@med.unipmn.it

Blood ; 119(12): 2854-62, 2012 Mar 22.

Article in En | MEDLINE | ID: mdl-22308293

Subject(s)

Antineoplastic Agents/therapeutic use; Drug Resistance, Neoplasm/genetics; Inhibitor of Apoptosis Proteins/genetics; Leukemia, Lymphocytic, Chronic, B-Cell/genetics; Tumor Suppressor Protein p53/genetics; Vidarabine/analogs & derivatives; Aged; Baculoviral IAP Repeat-Containing 3 Protein; Blotting, Western; DNA Mutational Analysis; Female; Humans; In Situ Hybridization, Fluorescence; Inhibitor of Apoptosis Proteins/metabolism; Kaplan-Meier Estimate; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/mortality; Male; Middle Aged; NF-kappa B/metabolism; Prognosis; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitin-Protein Ligases; Vidarabine/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Vidarabine / Leukemia, Lymphocytic, Chronic, B-Cell / Tumor Suppressor Protein p53 / Drug Resistance, Neoplasm / Inhibitor of Apoptosis Proteins / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Year: 2012 Type: Article

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