Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells.

Karman, Jozsef; Jiang, Ji-Lei; Gumlaw, Nathan; Zhao, Hongmei; Campos-Rivera, Juanita; Sancho, Jose; Zhang, Jinhua; Jiang, Canwen; Cheng, Seng H; Zhu, Yunxiang

Karman, Jozsef; Jiang, Ji-Lei; Gumlaw, Nathan; Zhao, Hongmei; Campos-Rivera, Juanita; Sancho, Jose; Zhang, Jinhua; Jiang, Canwen; Cheng, Seng H; Zhu, Yunxiang.

Affiliation

Karman J; Genzyme Corporation, Framingham, Massachusetts 01701-9322, USA.

J Biol Chem ; 287(14): 11098-107, 2012 Mar 30.

Article in En | MEDLINE | ID: mdl-22337882

Subject(s)

CTLA-4 Antigen/metabolism; Cell Differentiation; Forkhead Transcription Factors/metabolism; Receptors, Antigen, T-Cell/metabolism; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/metabolism; Animals; Autocrine Communication/drug effects; Cell Differentiation/drug effects; Female; Gene Expression Regulation/drug effects; HLA Antigens/metabolism; Mice; Protein Binding; Proto-Oncogene Proteins c-akt/metabolism; Recombinant Fusion Proteins/pharmacology; Signal Transduction/drug effects; Substrate Specificity; T-Lymphocytes, Regulatory/drug effects; TOR Serine-Threonine Kinases/metabolism; Transforming Growth Factor beta/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Cell Differentiation / T-Lymphocytes, Regulatory / Forkhead Transcription Factors / CTLA-4 Antigen Limits: Animals Language: En Year: 2012 Type: Article

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