Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.

Grzegorzewicz, Anna E; Pham, Ha; Gundi, Vijay A K B; Scherman, Michael S; North, Elton J; Hess, Tamara; Jones, Victoria; Gruppo, Veronica; Born, Sarah E M; Korduláková, Jana; Chavadi, Sivagami Sundaram; Morisseau, Christophe; Lenaerts, Anne J; Lee, Richard E; McNeil, Michael R; Jackson, Mary

Grzegorzewicz, Anna E; Pham, Ha; Gundi, Vijay A K B; Scherman, Michael S; North, Elton J; Hess, Tamara; Jones, Victoria; Gruppo, Veronica; Born, Sarah E M; Korduláková, Jana; Chavadi, Sivagami Sundaram; Morisseau, Christophe; Lenaerts, Anne J; Lee, Richard E; McNeil, Michael R; Jackson, Mary.

Affiliation

Grzegorzewicz AE; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.

Nat Chem Biol ; 8(4): 334-41, 2012 Feb 19.

Article in En | MEDLINE | ID: mdl-22344175

Subject(s)

Adamantane/analogs & derivatives; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Cell Membrane/metabolism; Mycobacterium tuberculosis/drug effects; Mycolic Acids/metabolism; Phenylurea Compounds/pharmacology; Adamantane/chemistry; Adamantane/pharmacology; Anti-Bacterial Agents/pharmacokinetics; Bacterial Proteins/metabolism; Biological Transport/drug effects; Cell Membrane/drug effects; Cord Factors; Drug Evaluation, Preclinical/methods; Drug Resistance, Bacterial; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis/genetics; Mycobacterium tuberculosis/metabolism; Phenylurea Compounds/chemistry; Small Molecule Libraries; Trehalose/metabolism

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Full text: 1 Database: MEDLINE Main subject: Phenylurea Compounds / Adamantane / Cell Membrane / Anti-Bacterial Agents / Mycobacterium tuberculosis / Mycolic Acids Type of study: Prognostic_studies Language: En Year: 2012 Type: Article

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