Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.

Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki

Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki.

Affiliation

Negoro K; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. kenji.negoro@astellas.com

Bioorg Med Chem ; 20(7): 2369-75, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22365911

Subject(s)

Cyclic N-Oxides/chemical synthesis; Pyridines/chemical synthesis; Pyrimidines/chemistry; Receptors, G-Protein-Coupled/agonists; Administration, Oral; Animals; Cyclic N-Oxides/chemistry; Cyclic N-Oxides/pharmacokinetics; HEK293 Cells; Humans; Male; Mice; Mice, Inbred ICR; Pyridines/chemistry; Pyridines/pharmacokinetics; Pyrimidines/chemical synthesis; Pyrimidines/pharmacokinetics; Rats; Receptors, G-Protein-Coupled/metabolism; Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Pyridines / Pyrimidines / Cyclic N-Oxides / Receptors, G-Protein-Coupled Limits: Animals / Humans / Male Language: En Year: 2012 Type: Article

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