Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.

Migliardi, Giorgia; Sassi, Francesco; Torti, Davide; Galimi, Francesco; Zanella, Eugenia R; Buscarino, Michela; Ribero, Dario; Muratore, Andrea; Massucco, Paolo; Pisacane, Alberto; Risio, Mauro; Capussotti, Lorenzo; Marsoni, Silvia; Di Nicolantonio, Federica; Bardelli, Alberto; Comoglio, Paolo M; Trusolino, Livio; Bertotti, Andrea

Migliardi, Giorgia; Sassi, Francesco; Torti, Davide; Galimi, Francesco; Zanella, Eugenia R; Buscarino, Michela; Ribero, Dario; Muratore, Andrea; Massucco, Paolo; Pisacane, Alberto; Risio, Mauro; Capussotti, Lorenzo; Marsoni, Silvia; Di Nicolantonio, Federica; Bardelli, Alberto; Comoglio, Paolo M; Trusolino, Livio; Bertotti, Andrea.

Affiliation

Migliardi G; Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment (IRCC), Candiolo, Italy.

Clin Cancer Res ; 18(9): 2515-25, 2012 May 01.

Article in En | MEDLINE | ID: mdl-22392911

Subject(s)

1-Phosphatidylinositol 4-Kinase/antagonists & inhibitors; Colorectal Neoplasms/prevention & control; Genes, ras; Liver Neoplasms/prevention & control; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mutation/genetics; TOR Serine-Threonine Kinases/antagonists & inhibitors; 1-Phosphatidylinositol 4-Kinase/metabolism; Aged; Aged, 80 and over; Animals; Case-Control Studies; Cell Line, Tumor; Colon/metabolism; Colon/pathology; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Humans; Immunoenzyme Techniques; Liver Neoplasms/metabolism; Liver Neoplasms/secondary; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Mitogen-Activated Protein Kinase Kinases/metabolism; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins B-raf/antagonists & inhibitors; Proto-Oncogene Proteins B-raf/metabolism; Rectum/metabolism; Rectum/pathology; TOR Serine-Threonine Kinases/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Genes, ras / 1-Phosphatidylinositol 4-Kinase / Mitogen-Activated Protein Kinase Kinases / TOR Serine-Threonine Kinases / Liver Neoplasms / Mutation Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Year: 2012 Type: Article

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