Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

Refaie, Sarah; Gagnon, Sandra; Gagnon, Hugo; Desjardins, Roxane; D'Anjou, François; D'Orléans-Juste, Pedro; Zhu, Xiaorong; Steiner, Donald F; Seidah, Nabil G; Lazure, Claude; Salzet, Michel; Day, Robert

Refaie, Sarah; Gagnon, Sandra; Gagnon, Hugo; Desjardins, Roxane; D'Anjou, François; D'Orléans-Juste, Pedro; Zhu, Xiaorong; Steiner, Donald F; Seidah, Nabil G; Lazure, Claude; Salzet, Michel; Day, Robert.

Affiliation

Refaie S; Institut de pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada.

J Biol Chem ; 287(18): 14703-17, 2012 Apr 27.

Article in En | MEDLINE | ID: mdl-22396549

Subject(s)

Cytokines/immunology; Gene Expression Regulation, Enzymologic/immunology; Immunity, Innate; Macrophages, Peritoneal/immunology; Proprotein Convertase 1/immunology; Animals; Cytokines/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Enzymologic/genetics; Immune System Diseases/genetics; Immune System Diseases/immunology; Immune System Diseases/metabolism; Immune System Diseases/pathology; Inflammation/genetics; Inflammation/immunology; Inflammation/pathology; Lipopolysaccharides/pharmacology; Macrophages, Peritoneal/metabolism; Macrophages, Peritoneal/ultrastructure; Mice; Mice, Knockout; Proprotein Convertase 1/biosynthesis; Proprotein Convertase 1/genetics; Th1 Cells/enzymology; Th1 Cells/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Gene Expression Regulation, Enzymologic / Cytokines / Macrophages, Peritoneal / Proprotein Convertase 1 / Immunity, Innate Type of study: Etiology_studies Limits: Animals Language: En Year: 2012 Type: Article

Fulltext

XML

PubMed Links

Search on Google