Effectiveness and safe use of modified FOLFOX-6 for metastatic gastric cancer with signet ring cell components complicated by disseminated intravascular coagulation and diffuse bone marrow carcinomatosis.

Ferrand, François-Régis; Gontier, Eric; Guymar, Sophie; Fagot, Thierry; Ceccaldi, Bernard; Malfuson, Jean-Valère; de Revel, Thierry

Ferrand, François-Régis; Gontier, Eric; Guymar, Sophie; Fagot, Thierry; Ceccaldi, Bernard; Malfuson, Jean-Valère; de Revel, Thierry.

Affiliation

Ferrand FR; Service d'oncologie, HIA Val de Grâce, Paris, France. francoisregisferrand@gmail.com

Onkologie ; 35(3): 118-20, 2012.

Article in En | MEDLINE | ID: mdl-22414976

ABSTRACT

ABSTRACT

We report the case of a 62-year-old woman with a metastatic gastric cancer complicated by diffuse bone marrow carcinomatosis, disseminated intravascular coagulation (DIC) and microangiopathic hemolytic anemia (MHA) treated by modified FOLFOX-6 as front-line chemotherapy regimen. This chemotherapy showed clinical, morphological and biological efficiency and safety in this rare and severe hematological complication at initial diagnosis. Furthermore, this is the first case of diffuse bone carcinomatosis from a gastric cancer to be monitored by positron emission tomography integrated computed tomography (PET-CT) scan using 18-fluorodeoxyglucose (18-FDG).

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bone Marrow Neoplasms/complications; Bone Marrow Neoplasms/drug therapy; Carcinoma, Signet Ring Cell/drug therapy; Carcinoma/complications; Carcinoma/drug therapy; Disseminated Intravascular Coagulation/complications; Stomach Neoplasms/drug therapy; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Antineoplastic Combined Chemotherapy Protocols/toxicity; Bone Marrow Neoplasms/pathology; Carcinoma/pathology; Carcinoma, Signet Ring Cell/pathology; Diagnostic Imaging; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Fatal Outcome; Female; Fluorouracil/administration & dosage; Fluorouracil/toxicity; Follow-Up Studies; Humans; Leucovorin/administration & dosage; Leucovorin/toxicity; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Organoplatinum Compounds/administration & dosage; Organoplatinum Compounds/toxicity; Purpura, Thrombotic Thrombocytopenic/complications; Purpura, Thrombotic Thrombocytopenic/drug therapy; Purpura, Thrombotic Thrombocytopenic/pathology; Sensitivity and Specificity; Stomach Neoplasms/pathology; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Stomach Neoplasms / Carcinoma / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Signet Ring Cell / Bone Marrow Neoplasms / Disseminated Intravascular Coagulation Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Middle aged Language: En Year: 2012 Type: Article

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