Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice.

Fei, Dongsheng; Meng, Xianglin; Kang, Kai; Nan, Chuanchuan; Zhao, Mingran; Pan, Shangha; Gao, Meizhuo; Yang, Songlin; Zhao, Mingyan

Fei, Dongsheng; Meng, Xianglin; Kang, Kai; Nan, Chuanchuan; Zhao, Mingran; Pan, Shangha; Gao, Meizhuo; Yang, Songlin; Zhao, Mingyan.

Affiliation

Fei D; Department of ICU, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Exp Lung Res ; 38(4): 173-82, 2012 May.

Article in En | MEDLINE | ID: mdl-22417130

Subject(s)

Acute Lung Injury/metabolism; Heme Oxygenase-1/metabolism; Protein C/metabolism; Thrombomodulin/blood; Acute Lung Injury/blood; Acute Lung Injury/etiology; Acute Lung Injury/prevention & control; Animals; Cecum; Enzyme Induction/drug effects; Enzyme Inhibitors/pharmacology; Heme Oxygenase-1/antagonists & inhibitors; Heme Oxygenase-1/biosynthesis; Hemin/pharmacology; Ligation; Lung/metabolism; Male; Mice; Mice, Inbred C57BL; Protoporphyrins/pharmacology; Punctures; Sepsis/complications

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Full text: 1 Database: MEDLINE Main subject: Protein C / Thrombomodulin / Heme Oxygenase-1 / Acute Lung Injury Type of study: Etiology_studies Limits: Animals Language: En Year: 2012 Type: Article

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