Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease.

Duan, Maosheng; Kazmierski, Wieslaw; Crosby, Renae; Gartland, Margaret; Ji, Jinjing; Tallant, Matt; Wang, Amy; Hamatake, Robert; Wright, Lois; Wu, Min; Zhang, Yong-Kang; Ding, Charles Z; Li, Xianfeng; Liu, Yang; Zhang, Suoming; Zhou, Yasheen; Plattner, Jacob J; Baker, Stephen J

Duan, Maosheng; Kazmierski, Wieslaw; Crosby, Renae; Gartland, Margaret; Ji, Jinjing; Tallant, Matt; Wang, Amy; Hamatake, Robert; Wright, Lois; Wu, Min; Zhang, Yong-Kang; Ding, Charles Z; Li, Xianfeng; Liu, Yang; Zhang, Suoming; Zhou, Yasheen; Plattner, Jacob J; Baker, Stephen J.

Affiliation

Duan M; Infectious Disease CEDD, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. duanmaosheng@hdbiosciences.com

Bioorg Med Chem Lett ; 22(8): 2993-6, 2012 Apr 15.

Article in En | MEDLINE | ID: mdl-22425454

Subject(s)

Drug Discovery; Hepacivirus/drug effects; Protease Inhibitors/chemical synthesis; Protease Inhibitors/pharmacology; Viral Nonstructural Proteins/antagonists & inhibitors; Cyclopropanes; Hepacivirus/genetics; Humans; Hydroxylation; Inhibitory Concentration 50; Isoindoles; Lactams/chemistry; Lactams/pharmacology; Lactams, Macrocyclic; Molecular Structure; Mutation; Proline/analogs & derivatives; Protease Inhibitors/chemistry; Sulfonamides/chemistry; Sulfonamides/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Viral Nonstructural Proteins / Hepacivirus / Drug Discovery Limits: Humans Language: En Year: 2012 Type: Article

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