Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.

Leonardi, Roberta; Subramanian, Chitra; Jackowski, Suzanne; Rock, Charles O

Leonardi, Roberta; Subramanian, Chitra; Jackowski, Suzanne; Rock, Charles O.

Affiliation

Leonardi R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

J Biol Chem ; 287(18): 14615-20, 2012 Apr 27.

Article in En | MEDLINE | ID: mdl-22442146

Subject(s)

Isocitrate Dehydrogenase; Mitochondrial Proteins; NADP/metabolism; Neoplasm Proteins; Neoplasms; Acetyl Coenzyme A/genetics; Acetyl Coenzyme A/metabolism; Cell Hypoxia/genetics; Cell Line, Tumor; Humans; Isocitrate Dehydrogenase/genetics; Isocitrate Dehydrogenase/metabolism; Mitochondria/genetics; Mitochondria/metabolism; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Mutation; NADP/genetics; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplasms/enzymology; Neoplasms/genetics; Oxidation-Reduction

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Full text: 1 Database: MEDLINE Main subject: Mitochondrial Proteins / Isocitrate Dehydrogenase / NADP / Neoplasm Proteins / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2012 Type: Article

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