Compound 49b prevents diabetes-induced apoptosis through increased IGFBP-3 levels.

Zhang, Qiuhua; Guy, Kimberly; Pagadala, Jayaprakash; Jiang, Youde; Walker, Robert J; Liu, Luhong; Soderland, Carl; Kern, Timothy S; Ferry, Robert; He, Hui; Yates, C Ryan; Miller, Duane D; Steinle, Jena J

Zhang, Qiuhua; Guy, Kimberly; Pagadala, Jayaprakash; Jiang, Youde; Walker, Robert J; Liu, Luhong; Soderland, Carl; Kern, Timothy S; Ferry, Robert; He, Hui; Yates, C Ryan; Miller, Duane D; Steinle, Jena J.

Affiliation

Zhang Q; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Invest Ophthalmol Vis Sci ; 53(6): 3004-13, 2012 May 17.

Article in En | MEDLINE | ID: mdl-22467575

Subject(s)

Adrenergic beta-Agonists/pharmacology; Apoptosis/drug effects; Diabetes Mellitus, Experimental/pathology; Diabetic Retinopathy/prevention & control; Insulin-Like Growth Factor Binding Protein 3/metabolism; Retina/pathology; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases/genetics; Diabetic Retinopathy/pathology; Dose-Response Relationship, Drug; Electroretinography; Endothelial Cells/metabolism; Endothelial Cells/pathology; Enzyme-Linked Immunosorbent Assay; Heart Ventricles/pathology; Insulin-Like Growth Factor Binding Protein 3/genetics; Male; Ophthalmic Solutions; RNA, Small Interfering; Rats; Retina/metabolism; Retinal Ganglion Cells/pathology; Retinal Vessels/drug effects; Retinal Vessels/metabolism; Retinal Vessels/pathology; Vitreous Body/chemistry

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Full text: 1 Database: MEDLINE Main subject: Retina / Apoptosis / Adrenergic beta-Agonists / Insulin-Like Growth Factor Binding Protein 3 / Diabetes Mellitus, Experimental / Diabetic Retinopathy Limits: Animals Language: En Year: 2012 Type: Article

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