Etravirine concentrations in the cervicovaginal compartment in HIV-1-infected women receiving etravirine-containing antiretroviral therapy: DIVA 02 study.
Antimicrob Agents Chemother
; 56(7): 4018-20, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22526321
ABSTRACT
We studied the penetration of etravirine and HIV shedding in the genital tract among 12 HIV-1-infected women receiving an etravirine-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median etravirine concentrations were 663 ng/ml in BP and 857 ng/ml in CVF, with a CVF/BP etravirine ratio of approximately 1.2. This good penetration of etravirine may contribute to the control of viral replication in the female genital tract.
Full text:
1
Database:
MEDLINE
Main subject:
Pyridazines
/
Vagina
/
HIV Infections
/
Cervix Uteri
/
Anti-HIV Agents
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Year:
2012
Type:
Article