Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer.

Yao, Xin; Ahmadzadeh, Mojgan; Lu, Yong-Chen; Liewehr, David J; Dudley, Mark E; Liu, Fang; Schrump, David S; Steinberg, Seth M; Rosenberg, Steven A; Robbins, Paul F

Yao, Xin; Ahmadzadeh, Mojgan; Lu, Yong-Chen; Liewehr, David J; Dudley, Mark E; Liu, Fang; Schrump, David S; Steinberg, Seth M; Rosenberg, Steven A; Robbins, Paul F.

Affiliation

Yao X; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. xiny@mail.nih.gov

Blood ; 119(24): 5688-96, 2012 Jun 14.

Article in En | MEDLINE | ID: mdl-22555974

Subject(s)

CD4 Antigens/metabolism; Forkhead Transcription Factors/metabolism; Immunotherapy, Adoptive/methods; Neoplasms/immunology; Neoplasms/therapy; T-Lymphocytes, Regulatory/immunology; CD8-Positive T-Lymphocytes/immunology; Cells, Cultured; Dose-Response Relationship, Immunologic; Humans; Interleukin-2/administration & dosage; Interleukin-2/immunology; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating/immunology; Phenotype; Treatment Outcome; Whole-Body Irradiation

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Full text: 1 Database: MEDLINE Main subject: CD4 Antigens / Immunotherapy, Adoptive / T-Lymphocytes, Regulatory / Forkhead Transcription Factors / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Year: 2012 Type: Article

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