Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.

Misso, Gabriella; Giuberti, Gaia; Lombardi, Angela; Grimaldi, Anna; Ricciardiello, Filippo; Giordano, Antonio; Tagliaferri, Pierosandro; Abbruzzese, Alberto; Caraglia, Michele

Misso, Gabriella; Giuberti, Gaia; Lombardi, Angela; Grimaldi, Anna; Ricciardiello, Filippo; Giordano, Antonio; Tagliaferri, Pierosandro; Abbruzzese, Alberto; Caraglia, Michele.

Affiliation

Misso G; Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, Naples, Italy.

J Cell Physiol ; 228(1): 130-41, 2013 Jan.

Article in En | MEDLINE | ID: mdl-22566192

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Squamous Cell/drug therapy; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Head and Neck Neoplasms/drug therapy; ras Proteins/antagonists & inhibitors; Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Benzoquinones/pharmacology; Benzoquinones/therapeutic use; Carcinoma, Squamous Cell/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Docetaxel; Drug Synergism; Gene Expression Regulation, Neoplastic/drug effects; HSP90 Heat-Shock Proteins/genetics; HSP90 Heat-Shock Proteins/metabolism; Head and Neck Neoplasms/metabolism; Humans; Lactams, Macrocyclic/pharmacology; Lactams, Macrocyclic/therapeutic use; Quinolones/pharmacology; Quinolones/therapeutic use; Signal Transduction/drug effects; Taxoids/pharmacology; Taxoids/therapeutic use; ras Proteins/genetics; ras Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Squamous Cell / Ras Proteins / HSP90 Heat-Shock Proteins / Head and Neck Neoplasms / Antineoplastic Agents Limits: Humans Language: En Year: 2013 Type: Article

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