Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage.

Sanz-García, Marta; Monsalve, Diana M; Sevilla, Ana; Lazo, Pedro A

Sanz-García, Marta; Monsalve, Diana M; Sevilla, Ana; Lazo, Pedro A.

Affiliation

Sanz-García M; Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas-Universidad de Salamanca, Campus Miguel de Unamuno, E-37007 Salamanca, Spain.

J Biol Chem ; 287(28): 23757-68, 2012 Jul 06.

Article in En | MEDLINE | ID: mdl-22621922

Subject(s)

DNA Damage; Intracellular Signaling Peptides and Proteins/metabolism; Protein Serine-Threonine Kinases/metabolism; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Checkpoint Kinase 2; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; HEK293 Cells; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins/genetics; Microscopy, Confocal; Mutation; Nucleosomes/enzymology; Nucleosomes/genetics; Nucleosomes/radiation effects; Phosphorylation/radiation effects; Protein Binding; Protein Serine-Threonine Kinases/genetics; RNA Interference; Radiation, Ionizing; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Tumor Suppressor p53-Binding Protein 1

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Full text: 1 Database: MEDLINE Main subject: DNA Damage / Protein Serine-Threonine Kinases / Intracellular Signaling Peptides and Proteins Limits: Humans Language: En Year: 2012 Type: Article

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