An unusual case of an osteosarcoma arising in a leiomyoma of the uterus.
Ann Saudi Med
; 32(5): 544-6, 2012.
Article
in En
| MEDLINE
| ID: mdl-22634486
ABSTRACT
Leiomyoma is the most common uterine neoplasm. It has several histological variants such as atypical, cellular, myxoid, and epithelioid. Leiomyoma with heterologous elements is a rare variant of leiomyoma, which may contain heterologous elements such as fat, skeletal muscle, and chondroid and osseous tissues. The heterologous sarcomatous differentiation is also rarely seen. We report on a 53-year-old woman who was admitted with abnormal vaginal bleeding and symptoms related to an abdominal mass. She had a huge uterine leiomyoma that contained osteosarcomatous differentiation in several foci. Although malignant progression for leiomyoma is exceedingly rare, when it occurs it may result not only in a leiomyosarcoma but also in a heterologous sarcomatous differention. We have reported histopathological, immunohistochemical, and clinical features of this rare case and reviewed the published studies.
Full text:
1
Database:
MEDLINE
Main subject:
Uterine Neoplasms
/
Osteosarcoma
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Leiomyoma
/
Neoplasms, Multiple Primary
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Year:
2012
Type:
Article