Toward fast determination of protein stability maps: experimental and theoretical analysis of mutants of a Nocardiopsis prasina serine protease.

Farrell, Damien; Webb, Helen; Johnston, Michael A; Poulsen, Thomas A; O'Meara, Fergal; Christensen, Lars L H; Beier, Lars; Borchert, Torben V; Nielsen, Jens Erik

Farrell, Damien; Webb, Helen; Johnston, Michael A; Poulsen, Thomas A; O'Meara, Fergal; Christensen, Lars L H; Beier, Lars; Borchert, Torben V; Nielsen, Jens Erik.

Affiliation

Farrell D; School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Biochemistry ; 51(26): 5339-47, 2012 Jul 03.

Article in En | MEDLINE | ID: mdl-22668005

Subject(s)

Actinomycetales/enzymology; Serine Proteases/chemistry; Serine Proteases/metabolism; Calorimetry, Differential Scanning; Circular Dichroism; Mutation; Protein Stability; Serine Proteases/genetics; Structure-Activity Relationship

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