Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors.

Jadhav, Ravindra D; Kadam, Kishorkumar S; Kandre, Shivaji; Guha, Tandra; Reddy, M Mahesh Kumar; Brahma, Manoja K; Deshmukh, Nitin J; Dixit, Amol; Doshi, Lalit; Potdar, Nisha; Enose, Arno A; Vishwakarma, Ram A; Sivaramakrishnan, H; Srinivasan, Shaila; Nemmani, Kumar V S; Gupte, Amol; Gangopadhyay, Ashok K; Sharma, Rajiv

Jadhav, Ravindra D; Kadam, Kishorkumar S; Kandre, Shivaji; Guha, Tandra; Reddy, M Mahesh Kumar; Brahma, Manoja K; Deshmukh, Nitin J; Dixit, Amol; Doshi, Lalit; Potdar, Nisha; Enose, Arno A; Vishwakarma, Ram A; Sivaramakrishnan, H; Srinivasan, Shaila; Nemmani, Kumar V S; Gupte, Amol; Gangopadhyay, Ashok K; Sharma, Rajiv.

Affiliation

Jadhav RD; Department of Medicinal Chemistry, Piramal Healthcare Limited, Goregaon (E), Mumbai 400 063, Maharashtra, India.

Eur J Med Chem ; 54: 324-42, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22683241

Subject(s)

Diacylglycerol O-Acyltransferase/antagonists & inhibitors; Isoxazoles/chemical synthesis; Isoxazoles/pharmacology; Oxadiazoles/chemical synthesis; Oxadiazoles/pharmacology; Urea/chemistry; Animals; Chemistry Techniques, Synthetic; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Humans; Inhibitory Concentration 50; Isoxazoles/chemistry; Mice; Oxadiazoles/chemistry; Solubility; Structure-Activity Relationship; Water/chemistry

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Full text: 1 Database: MEDLINE Main subject: Oxadiazoles / Urea / Diacylglycerol O-Acyltransferase / Isoxazoles Limits: Animals / Humans Language: En Year: 2012 Type: Article

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