Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein.

Grasso, Felicia; Negri, Donatella R M; Mochi, Stefania; Rossi, Alessandra; Cesolini, Armando; Giovannelli, Andrea; Chiantore, Maria Vincenza; Leone, Pasqualina; Giorgi, Colomba; Cara, Andrea

Grasso, Felicia; Negri, Donatella R M; Mochi, Stefania; Rossi, Alessandra; Cesolini, Armando; Giovannelli, Andrea; Chiantore, Maria Vincenza; Leone, Pasqualina; Giorgi, Colomba; Cara, Andrea.

Affiliation

Grasso F; Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

Int J Cancer ; 132(2): 335-44, 2013 Jan 15.

Article in En | MEDLINE | ID: mdl-22700466

Subject(s)

Cancer Vaccines/administration & dosage; Integrases/genetics; Lentivirus/genetics; Papillomavirus E7 Proteins/genetics; Papillomavirus Infections/prevention & control; Uterine Cervical Neoplasms/prevention & control; Animals; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; CD8-Positive T-Lymphocytes/virology; Calreticulin/biosynthesis; Calreticulin/genetics; Calreticulin/immunology; Cancer Vaccines/therapeutic use; Cell Line, Tumor; Female; Gene Expression; Genetic Vectors; Humans; Immunity, Cellular; Immunity, Humoral; Interferon-gamma/metabolism; Kaplan-Meier Estimate; Lentivirus/enzymology; Mice; Mice, Inbred C57BL; Papillomavirus E7 Proteins/biosynthesis; Papillomavirus E7 Proteins/immunology; Papillomavirus Infections/immunology; Papillomavirus Infections/pathology; Papillomavirus Infections/virology; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/immunology; Tumor Burden; Uterine Cervical Neoplasms/immunology; Uterine Cervical Neoplasms/pathology; Uterine Cervical Neoplasms/virology; Vaccination; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Lentivirus / Integrases / Cancer Vaccines / Papillomavirus Infections / Papillomavirus E7 Proteins Type of study: Prognostic_studies / Risk_factors_studies Language: En Year: 2013 Type: Article

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